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Pemetrexed

Pemetrexed

Product Details:

  • Formulations Type Injectables
  • Formulations Form Liquid
  • Gender/Age Group Adult
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Product Specifications

  • Adult
  • Injectables
  • Liquid

Trade Information

  • Cash on Delivery (COD), Cash Advance (CA), Delivery Point (DP), Western Union
  • Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
  • All India

Product Description

Pemetrexed (brand name Alimta) is a chemotherapy drug manufactured and marketed by Eli Lilly and Company. Its indications are the treatment of pleural mesothelioma and non-small cell lung cancer.

Medical use

In February 2004, the Food and Drug Administration approved pemetrexed for treatment of malignant pleural mesothelioma, a type of tumor of the lining of the lung, in combination with cisplatin[1] for patients whose disease is either unresectable or who are not otherwise candidates for curative surgery.[2] In September 2008, the FDA granted approval as a first-line treatment, in combination with cisplatin, against locally advanced and metastatic non-small cell lung cancer (NSCLC) in patients with non-squamous histology.[3][4][5] A Phase III study showed benefits of maintenance use of pemetrexed for non-squamous NSCLC.[6] Activity has been shown in malignant peritoneal mesothelioma.[7] Trials are currently testing it against esophagus and other cancers.

Carboplatin

Pemetrexed is also recommended in combination with carboplatin for the first-line treatment of advanced non-small cell lung cancer.[8] However, the relative efficacy or toxicity of pemetrexed-cisplatin versus pemetrexed-carboplatin has not been established beyond what is generally thought about cisplatin or carboplatin doublet drug therapy[9]

Supplementation

Patients should take folic acid and vitamin B12 supplement even if levels are normal when they are on pemetrexed therapy.[10][11] (In clinical trials for mesothelioma, folic acid and B12 supplementation reduced the frequency of adverse events.) It is also recommended for patients to be on a steroid (e.g., dexamethasone 4 mg twice daily) on the day prior, day of, and day after Pemetrexed infusion to avoid skin rashes.[12]

 


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