Cyclophosphamide

We have marked a great niche in the industry of medicines by supplying quality check Cyclophosphamide. An anti- cancer medicine, it belongs to a class of drugs called antineoplastic or cytotoxic agents. The Cyclophosphamide medicine is highly effective in the treatment of Burkitt�s lymphoma, Hodgkin�s and non- Hodgkin�s lymphoma, chronic myelocytic leukemia (CML), chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), acute myelocytic leukemia (AML), multiple myeloma and neuroblastoma. 

Key points:

• Considered as the best chemotherapy drug

  Classified as an alkylating agent

  Prolonged shelf life

Description

Zuviphos is cyclophosphamide for injection. It is a white powder having a low melting point of 49.5 to 50 C. Cyclophosphamide is chemically 2 - [bis-(2-chloroethyl) - amino] tetrahydro-2H-1, 3,2-oxazaphosphorine-2-oxide, corresponding to the molecular formula C7H15C12N2O2PH2O and a molecular weight of cyclophosphamide is 279.1.  Cyclophosphamide is a pro-drug and needs to be converted into an active metabolite in the liver. It is an anticancer drug with a broad-spectrum activity exerting its effect by interfering with G2 & S-phase of the cell cycle.

A powerful immune suppressant, Cyclophosphamide is a component of conditioning regimens for organ and tissue transplants. It has also been used in the treatment of some autoimmune disease such as refractory rheumatoid arthritis, systemic lupus erythematosus, autoimmune haemolytic anaemia, nephrotic syndrome, only after failure with conventional therapy. Cyclophosphamide is preferably administered by the intravenous route. It has been suggested to avoid IM injection because of inconsistent absorption, and delayed activation. For IV administration, a solution containing 20 mg/mL concentrations is generally recommended. It may be diluted further for infusion. The solution may be infused IV in D5W, or D5NS. It is a low melting substance and hence needs to be stored below 25 C. Although the aqueous solutions may be kept for a few hours at 25 C, at temperatures above 30 C cyclophosphamide gets hydrolyzed with loss of chlorine atom and hence loss of activity. Even the oral formulation of Cyclophosphamide needs to be preserved at temperatures less than 25 C. Zuviphos should be stored at controlled temperature between +15°C to +25°C.

Indications

Zuviphos is indicated in combination with other anticancer drugs in the treatment of metastatic breast cancer, ovarian cancer, cancer of the uterine cervix and endometrium, the Gestational Trophoblastic tumors, Oat Cell Bronchogenic Carcinoma, and Seminoma. It may also be used in the treatment of childhood malignancies such as Neuroblastoma, Retinoblastoma, and Wilm's tumor. Cyclophosphamide has also been successfully used in the treatment of Burkitt's lymphoma, Hodgkin's disease, non-Hodgkin's Lymphomas, the Chronic Lymphoblastic, Acute Myelogenous Leukemia, Plasmocytoma, Multiple Myeloma, Mycosis Fungoides, and Waldenstrom's disease. It has been also indicated for the treatment of the Osteosarcoma and Ewing's sarcoma. It may also be used for the treatment of biopsy proven, minimal change nephritic syndrome.

DESCRIPTION:

Zuviphos is cyclophosphamide for injection. It is a white powder having a low melting point of 49.5 to 50 C. Cyclophosphamide is chemically 2 - [bis-(2-chloroethyl) - amino] tetrahydro-2H-1, 3,2-oxazaphosphorine-2-oxide, corresponding to the molecular formula C7H15C12N2O2PH2O and a molecular weight of cyclophosphamide is 279.1.  Cyclophosphamide is a pro-drug and needs to be converted into an active metabolite in the liver. It is an anticancer drug with a broad-spectrum activity exerting its effect by interfering with G2 & S-phase of the cell cycle.